Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies

Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in context of certain major complex (HLA – human leucocyte antigen) alleles. One most common HLA alleles is HLA-A*02:01. Accordingly, for a significant number donors and recipients pairs, it possible use MiHAs presented HLA-A*02:01 as target relapsed leukemia therapy. This review discusses main known HLA-A*02:01, their characteristics approaches used identification. The described may be search new immunotherapy.